OXYTHIOQUINOX TOXICITY BY INTRAGASTRIC ADMINISTRATION IN LIPIDS SOLUTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 9  (5) , 295-301
Abstract
When oxythioquinox (Morestan) is administered to rats by stomach tubing, its toxicity is very strongly increased after solubilization in olive oil. The oxythioquinox LD50, in this case, is 500 mg/kg although 2.8 g/kg can be reached in aqueous suspensions. When it is administered (1 g/kg) in aqueous suspension, the decrease in body weight is the same as these observed with a 5-fold lower dose in oil. Feed conversion rate and weight of different organs decrease when animals are daily submitted to oxythioquinox in oil, during 16 days, compared with animals treated with an equivalent dose in aqueous suspension. Potentiation, in oil solutions, of the decrease of oxythioquinox intestinal transit, promoting its absorption, could explain the increase of oxythioquinox toxicity in oil solution.

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