Plasma Polymerized N-Isopropylacrylamide: Synthesis and Characterization of a Smart Thermally Responsive Coating

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Abstract
A lower critical solution temperature (LCST) in an aqueous environment has been observed with poly(N-isopropylacrylamide) (pNIPAM) deposited onto solid surfaces from a plasma glow discharge of NIPAM vapor. The synthesis and spectroscopic data (ESCA, FTIR) for the plasma polymerized NIPAM (ppNIPAM) shows a remarkable retention of the monomer structure. The phase transition at 29 °C was measured by a novel AFM method. The phase transition was surprising because of the expectation that the plasma environment would destroy the specific NIPAM structure associated with the thermal responsiveness. The phase change of ppNIPAM is also responsible for the changes in the level of the meniscus when coated capillaries are placed in warm and cold water. Plasma polymerization of NIPAM represents a one-step method to fabricate thermally responsive coatings on real-world biomaterials without the need for specially prepared substrates and functionalized polymers.