Low-dose Cytosine Arabinoside Therapy in a Patient with Myelofibrosis during Transformation to Acute Non-lymphocytic Leukemia

Abstract
A patient with myelofibrosis transforming into acute non-lymphocytic leukaemia (ANLL) was treated with low doses of cytosine arabinoside (ARA-C). Complete remission was obtained twice without serious toxicity. It is suggested that low-dose ARA-C may be an effective and rather non-toxic therapy in patients with myeloproliferative disorders transforming to ANLL.