Hypoglycemia and seizures in childhood

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Abstract
Twenty-seven infants and children were evaluated because of seizures associated with low levels of blood sugar. The hypoglycemia was cryptogenic in 20 patients and the etiology was known in 7 patients. The average age at onset of seizures was 1 year and 7 months in patients with cryptogenic hypoglycemia and 5 years in those with hypoglycemia of known etiology. Evidence for primary disease of the nervous system included birth injury, retarded development, abnormal neurologic signs, kernicterus, and pneumoencephalograms which showed communicating hydrocephalus and cerebral dysgenesis. A lack of correlation was observed between the degree of hypoglycemia and the occurrence of seizures in 20 patients who had blood sugar determinations at the onset of seizures and after fasting, which failed to induce seizures. Neurologic disease was primary and may have been responsible for both the hypoglycemia and seizures in 10 (50%) of 20 patients with cryptogenic hypoglycemia and in 1 patient with hypopituitarism.

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