Development and optimisation of a high-performance liquid chromatographic assay for tioconazole and its potential impurities. Part II. Selection of detection conditions for potential impurities
- 1 January 1989
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 114 (1) , 53-56
- https://doi.org/10.1039/an9891400053
Abstract
An optimised high-performance liquid chromatographic separation developed for the assay of tioconazole and its potential impurities has been applied to real-world samples where tioconazole is in excess. As severe peak tailing interferes with the assay of two of the impurity peaks, changes in detection wavelength have been examined as a means to discriminate between this interference. The resulting enhancement of resolution has been exploited in the optimisation of analysis time.Keywords
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