Plasma Endothelin-1 Levels in Stable and Unstable Angina

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Abstract
Plasma levels of endothelin-1 are elevated in acute myocardial infarction with higher levels in complicated infarctions. Measurements of levels in unstable angina could help clarify whether the elevation is the consequence of cell necrosis or is in some way related to the pathophysiology of acute coronary syndromes. Plasma endothelin-1 levels were determined by radioimmunoassay in 29 patients with unstable angina and 6 with a myocardial infarction. Blood samples were obtained at admission before drug administration and 6 and 72 h later. Levels were also determined in 27 control subjects and in 29 patients with stable angina. Admission levels were similar in unstable angina, 0.635 ± 0.052 pg/ml [log(l +x)], and myocardial infarction, 0.746 ± 0.122, and significantly higher than in controls, 0.428 ± 0.047, and stable angina patients, 0.449 ± 0.052 (p

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