Further studies on the prevention of tolerance induction by poly A:U.

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  • 1 October 1974
    • journal article
    • Vol. 27  (4) , 647-53
Abstract
Poly A:U, a complex of synthetic polyadenylic—polyuridylic acids, prevented tolerance induction to bovine gamma—globulin (BGG) in mice when administered 0-12 hours after a tolerogenic dose (500 μg) of BGG, as shown by haemagglutinin production and immune elimination of labelled antigen after challenge with 300 μg of aggregated BGG. Administration of poly A:U 3-6 hours after tolerogen appeared to be the most effective. It was found further that two doses of poly A:U given at 3 and 6 or 3 and 12 hours, or a double dose of 600 μg given at 3 hours after tolerogen did not increase its effectiveness beyond that of a single dose of 300 μg given at 3 hours.