The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 45 (3-4) , 174-176
- https://doi.org/10.1159/000132450
Abstract
Mouse Pvt-1 and rat MISl are frequent proviral integration sites in retrovirally induced lymphomas. The Pvt-1 locus is also involved in mouse plasmacytoma (6;15) and in the variant Burkitt lymphoma (2;8) translocations. We show that the Pvt-1/MISl locus is syntenic with MYC on rat chromosome 7. This is consistent with a postulate of close linkage and, possibly, a functional relationship between the MYC protoon-cogene and the MIS1/Pvt-1 locus.Keywords
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