Chemical stability of cyclophosphamide, trofosfamide, and 2- and 3-dechloroethylifosfamide in aqueous solutions
- 1 March 1996
- journal article
- other
- Published by SAGE Publications in Journal of Oncology Pharmacy Practice
- Vol. 2 (1) , 15-21
- https://doi.org/10.1177/107815529600200102
Abstract
The degradation kinetics of various oxazaphospho rines : trofosfamide, cyclophosphamide, and 2- and 3-dechloroethylifosfamide was studied by means of a high-performance liquid chromatographic method. The results were compared with the kinetics of ifosfamide. It appeared that the pres ence and the site of the chloroethyl group influ enced the chemical stability of the compounds.Keywords
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