Clastogenic Effect of TrenimonR on in Vitro Chromosomes of Phenotypically Healthy Subjects with Morphologically Abnormal Caryotype
- 1 January 1975
- journal article
- research article
- Published by Cambridge University Press (CUP) in Acta geneticae medicae et gemellologiae
- Vol. 24 (3-4) , 269-281
- https://doi.org/10.1017/s0001566000010382
Abstract
The effect of a given concentration of TrenimonR (6 × 20−8 mol/1) on the lymphocytes of 11 healthy subjects with morphologically abnormal karyotype was analysed in vitro. The research included 6 subjects with balanced translocations, one of them with a centric fusion. Of the remaining 5 subjects, 2 had a duplication in the paracentric region, 1 showed an inversion, and 2 had a marker chromosome. In the group with morphologically abnormal chromosomes a higher sensibility to the influence of TrenimonR was found as compared with a control group with morphologically normal karyotype. The subjects with an atypical karyotype had 36 to 65% aberrations, the control group 28%. A localization of the breaks showed no increased aberration rates in the morphologically abnormal chromosomes.Keywords
This publication has 1 reference indexed in Scilit:
- Spontaneous chromosome aberrations in human somatic cellsPublished by Springer Nature ,1972