4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: a new class of cardiotonic agents. 2. Effect of 4-pyridoyl substituents and related compounds
- 1 May 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (5) , 860-862
- https://doi.org/10.1021/jm00155a043
Abstract
A group of 4-pyridoyl-1,3-dihydro-2H-imidazol-2-ones was prepared and tested for inotropic activity in the anesthetized dog. Positive inotropic effects as well as increases in heart rate and decreases in blood pressure were noted for most of these compounds. One of the compounds (8) is currently undergoing clinical trials for the treatment of congestive heart failure.This publication has 6 references indexed in Scilit:
- Studies on the Mechanism of the Positive Inotropic Effect of Piroximone in Cat Papillary MuscleJournal of Cardiovascular Pharmacology, 1985
- STUDIES ON THE MECHANISM OF THE CARDIOTONIC ACTIVITY OF MDL-19205 - EFFECTS ON SEVERAL BIOCHEMICAL SYSTEMS1984
- In Vitro and In Vivo Assessment of the Cardiovascular Effects of the Cardiotonic Drug MDL 19205Journal of Cardiovascular Pharmacology, 1984
- Cardiovascular Properties of a New Cardiotonic Agent, MDL 19205Journal of Cardiovascular Pharmacology, 1984
- The acute hemodynamic effects of a new agent, MDL 17,043, in the treatment of congestive heart failure.Circulation, 1983
- 4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agentsJournal of Medicinal Chemistry, 1982