DC-52, a novel antitumor antibiotic. 1. Taxonomy, fermentation and biological activity.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (5) , 463-467
- https://doi.org/10.7164/antibiotics.36.463
Abstract
A novel antitumor antibiotic, DC-52 was found in the culture broths of actiomycete DO-52. The producing organism was subsequently determined to be a new species and named Streptomyces melanovinaceus sp. nov. For the production of the antibiotic, soluble starch served as a good C source and soybean meal was a good N source tested. The antibiotic DC-52 is active against Bacillus subtilis, Staphylococcus aureus and Klebsiella pneumoniae, but not active against most gram-negative bacteria. The antibiotic is also active against mouse leukemia P388.This publication has 1 reference indexed in Scilit:
- DC-52, a novel antitumor antibiotic. 2. Isolation, physico-chemical characteristics and structure determination.The Journal of Antibiotics, 1983