Bronchodilating activity of oral clenbuterol in asthmatic children after single administration of different dosages

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Abstract
The dose‐response activity of clenbuterol, a new long‐acting β2‐agonist, was evaluated in 12 children aged 5 to 11 years with moderate to severe asthma. The study was a double‐blind cross‐over comparison of three oral dose levels: 0.5, 1.0, and 1.5 μg/kg and placebo all in the form of syrup. Pulmonary function, heart rate, blood pressure, and tremor were evaluated at 30, 60, 90, and 120 min, then hourly for 8 hr, following the ingestion of the drug. The bronchodilating effect of clenbuterol, evaluated as percentage changes in expiratory flow rates was significantly different from placebo. The overall fall‐off in the effect of 1.0 μg/kg and 1.5 μg/kg doses after 8 hr was small. The results of the 1.0 μg/kg dose often overlapped those of the 1.5 μg/kg dose, suggesting that a single 1.0 μg/kg dose of clenbuterol is most advisable in children, assuring the most favorable risk/benefit ratio. Even the highest dose of clenbuterol caused only a marginal increase in tremor, not statistically different from that induced by placebo. Pediatr Pulmonol 1987; 3; 34–37.

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