Molecular characterisation of emergent multiresistant Salmonella enterica serotype [4,5,12:i:−] organisms causing human salmonellosis

15 September 2000

journal article
Published by Oxford University Press (OUP) in FEMS Microbiology Letters

Vol. 190 (2) , 341-347
https://doi.org/10.1016/s0378-1097(00)00359-1

Abstract

Salmonella multidrug-resistant clinical organisms identified as serotype [4,5,12:i:−] were typed using selected genetic procedures and compared with typhimurium organisms collected in the same Spanish region. Results showed a low genetic heterogeneity among [4,5,12:i:−] organisms, which generated identical ribotypes and similar but not identical Xba I PFGE, RAPD, and plasmid profiles. Multidrug resistance could be eliminated by curing and seems to be mediated by 140-kb ( spvC +) and 120-kb ( spvC −) non-self-transferable plasmids. The [4,5,12:i:−] organisms fall into a single genetic lineage, which emerged in 1997 and presents a different degree of genetic relationship with typhimurium lineages.

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