PERNICIOUS ANEMIA

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Abstract
In 1920, Whipple and his associates1reported a series of studies on blood regeneration following a simple experimental anemia in dogs. Their work indicated that dietetic factors were of much greater importance in influencing the rate of blood regeneration than iron administered as pills of ferrous carbonate. Of all the foodstuffs used, the most rapid blood regeneration followed the ingestion of cooked liver, cooked lean beef, and beef heart. No exact explanation was offered for the efficiency of liver in this regard. These observations were followed by a report by Gibson and Howard2in 1923 on the use of "Whipple's high iron diet," in a series of eleven cases of pernicious anemia, controlled by four other cases of anemia. Their conclusions were that "more favorable nitrogen and iron balances may be readily established in pernicious anemia when diets rich in food iron and comparatively low in calory and

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