A Highly Active Catalyst for the Room-Temperature Amination and Suzuki Coupling of Aryl Chlorides
- 6 August 1999
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 38 (16) , 2413-2416
- https://doi.org/10.1002/(sici)1521-3773(19990816)38:16<2413::aid-anie2413>3.0.co;2-h
Abstract
A unique combination of steric and electronic properties appears to determine the effectiveness of phosphanyl‐substituted biphenyls as ligands in palladium‐catalyzed aminations and Suzuki coupling of aryl chlorides at room temperature [Eq. (1)]. The oxidative addition step is greatly accelerated, and transmetalation (or Pd−N bond formation) and reductive elimination processes are facilitated. Use of these ligands allows for Suzuki coupling at very low catalyst loadings (as little as 10−6 mol % Pd). R″=cyclohexyl, tert‐butyl.Keywords
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