SELECTIVE INHIBITION BY PREPARATIONS OF STREPTOCOCCAL FILTRATES OF THE OXIDATIVE METABOLISM OF MITOCHONDRIA PROCURED FROM RABBIT MYOCARDIUM

Open Access
Publisher Website
Google Scholar
Abstract
When solutions of streptolysin O were added to Warburg flasks containing, among other constituents, suspensions of mitochondria from the myocardium of rabbits and citrate, fumarate, or alpha-ketoglutarate as the substrate, there followed regularly a sharp reduction, and eventually complete cessation, of oxygen consumption. This phenomenon was not observed when succinate was the substrate in the flasks, the finding pointing to a selective interference with DPN as the underlying change.