Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

1 May 2001

journal article
research article
Published by Springer Nature in Nature Immunology

Vol. 2 (5) , 403-409
https://doi.org/10.1038/87704

Abstract

Pre-T cell antigen receptor (pre-TCR) signaling plays a crucial role in the development of immature T cells. Although certain aspects of proximal pre-TCR signaling have been studied, the intermediate signal transducers and the distal transcription modulators have been poorly characterized. We report here a correlation between pre-TCR signaling and a biphasic rise in the cytosolic Ca²⁺ concentration. In addition, we show that constitutive pre-TCR signaling is associated with an increased rate of Ca²⁺ influx through store-operated plasma membrane Ca²⁺ channels. We show also that the biphasic nature of the observed pre-TCR–induced rise in cytosolic Ca²⁺ differentially modulates the activities of the transcription factors NF-κB and NFAT in developing T cells.

Keywords

TRANSCRIPTION FACTOR

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