SOME OBSERVATIONS ON PROGESTERONE ANESTHESIA IN THE RAT1

Abstract
Selye''s findings that the rat acquires resistance to the anesthetic effect of steroidal hormones were fully corroborated. It was found that prior injn. of estrogen did not have a "sensitizing" effect in rats made resistant to progesterone, but an additive effect, which is also in consonance with Selye''s results. Using Burge''s technique of measuring depth of anesthesia by fall in electrical potential of brain with reference to the gastrocnemius muscle, anesthesia by means of progesterone (or other steroid) differed in no wise from the effects of the usual anesthetics (cf. Farson, Carr, and Krantz, Proc. Soc. Exptl. Biol. and Med., 63: 70. 1946).

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