Urethral Pressure Profiles Before and After Ornade Administration in Patients With Stress Urinary Incontinence

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Abstract
Urethral pressure profilometry was done on 12 women with stress urinary incontinence and in 6 women with no history of incontinence, before and 1-2 h after Ornade administration. Of the 12 women with stress urinary incontinence, 11 had increased maximal urethral pressure of 20% or more over the control value. Only 1 of the 6 control women exhibited an increased maximal urethral pressure of > 20% after Ornade administration. The phenylpropanolamine component of Ornade evidently stimulates .alpha.-adrenergic receptors at the vesical neck and in the proximal urethra to achieve the therapeutic effect of reducing or eliminating stress urinary incontinence. This drug is preferred over ephedrine primarily because of its sustained release, allowing dosage twice a day, and because of its relative freedom from side effects. [Ornade contains 50 mg of an immediate and a sustained release form of the sympathomimetic agent, phenylpropanolamine hydrochloride, 8 mg chlorpheniramine maleate and 2.5 mg isopropamide iodide.].