The differences of the metabolism related to vitamin B6-dependent enzymes among vitamin B6-deficient germ-free and conventional rats.

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Abstract
There was a significant difference in the body weight gain between vitamin B6-deficient germ-free and conventional rats after about 30 days of the experiment; the body weight gain was much less in the deficient germ-free rats than in the deficient conventional ones. Urinary excretion of xanthurenic acid was higher in the deficient germ-free rats than in the deficient conventional ones after 18 days. There was a significant difference in the activities of kynurenine aminotransferase in mitochondrial fractions of conventional ones. The activities of aspartate and alanine aminotransferases (with or without pyridoxal phosphate) significantly decreased in the deficient germ-free rats, but not in the deficient conventional ones. The degree of vitamin B6 deficiency was more severe in the deficient germ-free rats than in the deficient conventional ones; intestinal microflora may have some effects on vitamin B6-deficient conventional rats.