Photoinduced transformations. Part 41. Photo-Beckmann rearrangement of some cholestan-3-one oximes with methyl groups attached to the α-carbon
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2920-2925
- https://doi.org/10.1039/p19790002920
Abstract
Methylation of 4,4-dimethyl-5α-cholestan-3-one with methyl iodide and base gave 2α,4,4-trimethyl-5α-cholestan-3-one and 2,2,4,4-tetramethyl-5α-cholestan-3-one as the major products. The photoreactions of 4,4-dimethyl-5α-cholestan-3-one oxime and 2α,4,4-trimethyl-5α-cholestan-3-one oxime afforded the corresponding 3-aza- and 4-aza-lactams, respectively, arising by a Beckmann-type rearrangement. In these photorearrangements no products resulting from α-fission are formed. These results contrast with those of the acid-catalysed reaction in which products resulting from second-order Beckmann rearrangement predominate.Keywords
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