Crystal structure at 2.2 Å resolution of the MHC-related neonatal Fc receptor
- 1 November 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 372 (6504) , 336-343
- https://doi.org/10.1038/372336a0
Abstract
The three-dimensional structure of the rat neonatal Fc receptor (FcRn) is similar to the structure of molecules of the major histocompatibility complex (MHC). The counterpart of the MHC peptide-binding site is closed in FcRn, making the FcRn groove incapable of binding peptides. A dimer of FcRn heterodimers seen in the crystals may represent a receptor dimer that forms when the Fc portion of a single immunoglobulin binds. An alternative use of the MHC fold for immune recognition is indicated by the FcRn and FcRn/Fc co-crystal structures.Keywords
This publication has 45 references indexed in Scilit:
- Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligandImmunity, 1994
- The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and releaseBiochemistry, 1993
- Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1Nature, 1993
- SETOR: Hardware-lighted three-dimensional solid model representations of macromoleculesJournal of Molecular Graphics, 1993
- Crystallization and Stoichiometry of Binding of a Complex between a Rat Intestinal Fc Receptor and FcJournal of Molecular Biology, 1993
- Thermal Stability Comparison of Purified Empty and Peptide-Filled Forms of a Class I MHC MoleculeScience, 1992
- Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresNature, 1992
- Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolutionJournal of Molecular Biology, 1991
- Structural Basis of Antibody FunctionAnnual Review of Immunology, 1983
- Heavy atom-labelled derivatives of bovine pancreatic ribonuclease: I. specific reactions of ribonuclease with N-acetylhomocysteine thiolactone and silver ionJournal of Molecular Biology, 1969