Chemical changes of human knee joint menisci in various stages of degeneration.
Open Access
- 1 August 1984
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 43 (4) , 635-640
- https://doi.org/10.1136/ard.43.4.635
Abstract
Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72% water, 0.12% DNA, 22% collagen, and 0.8% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40% chondroitin 6-sulphate, 10-20% chondroitin 4-sulphate, 20-30% dermatan sulphate, and 15% keratan sulphate. The water content increased with increasing degeneration, whereas the collagen and glycosaminoglycan contents decreased with relative increase of chondroitin 6-sulphate.Keywords
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