Response to Exogenous Gonadotrophins in Absence of Dietary Protein.

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Abstract
Adult female rats were given a protein-free diet for 5 weeks and their response to graded amounts of gonadotropic hormones determined. Protein-deficient rats responded to follicle stimulating hormone (FSH) with follicular growth at the same dosage levels as adult hypophysectomized rats of similar age and body weight. Interstitial cell stimulating hormone (ICSH), as judged by stimulation of interstitial tissue, was slightly more effective in protein-deficient than in hypophysectomized rats. Human chorionic gonadotropins (HCG) and pregnant mare serum gonadotropic hormones (PMS) induced follicular growth, corpus luteum formation and increased uterine weights in protein-deficient rats at 1/2 the dosages necessary in normal immature rats.