Glucagon Suppressed Proliferation Rate of Mammary Aplastic Carcinoma in Mice

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Abstract
Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum [Propionibacterium acnes] pretreated animals. The tumor-retarding effects of glucagon apparently are mediated mainly by maintaining high B [bone marrow-derived cell]-type reactivity and phagocytosis.