INDUCTIONS OF ORNITHINE DECARBOXYLASE AND DNA-SYNTHESIS IN RAT STOMACH MUCOSA BY 1-NITROSOINDOLE-3-ACETONITRILE
- 1 May 1987
- journal article
- research article
- Vol. 78 (5) , 432-435
Abstract
Administration of 1-nitrosoindole-3-acetonitrile (NIAN) at doses of 40 to 300 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 24 hr and up to 10-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that NIAN has potential tumor-promoting activity in carcinogenesis in the glandular stomach.This publication has 8 references indexed in Scilit:
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