Dicentric chromosome in the bone marrow of a child with megakaryoblastic leukaemia and Down's syndrome.
- 1 April 1988
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 41 (4) , 378-380
- https://doi.org/10.1136/jcp.41.4.378
Abstract
A two year old girl with Down''s syndrome (constitutional karyotype: 47 +21), presenting with pancytopenia, developed acute megakaryoblastic leukaemia (AMKL). Her bone marrow contained an abnormal clone with a novel dicentric chromosome derived from chromosomes 5 and 7 (karyotype 46, XX, -5, -7, + dic (5; 7) (p 13; p 11.2), +21). This case provides further evidence for a connection between chromosome 21 and this unusual from of childhood leukaemia, and raises questions about the loss of short arm material from chromosomes 5 and 7 compared with the more usual monosomy or long arm loss.Keywords
This publication has 23 references indexed in Scilit:
- Megakaryoblastic transformation of chronic myelogenous leukaemia in a childScandinavian Journal of Haematology, 2009
- Megakaryoblastic leukaemia and myelofibrosis complicating Fanconi anaemiaScandinavian Journal of Haematology, 2009
- Acute megakaryoblastic leukaemia in childrenBritish Journal of Haematology, 1986
- Chromosome clues to acute leukemia in Down's syndromeCancer Genetics and Cytogenetics, 1986
- Leukemia in a trisomy 21 mosaic: Specific involvement of the trisomic cellsCancer Genetics and Cytogenetics, 1986
- Acute megakaryoblastic leukemia in down's syndrome: Report of a case and review of cytogenetic findingsMedical and Pediatric Oncology, 1985
- Acute megakaryoblastic leukaemia associated with intrinsic platelet dysfunction and constitutional ring 21 chromosome in a young boyBritish Journal of Haematology, 1982
- DOWN SYNDROME AND LEUKAEMIAThe Lancet, 1981
- DOWN SYNDROME AND ACUTE LEUKAEMIA: INCREASED RISK MAY BE DUE TO TRISOMY 21The Lancet, 1981
- Acute myelofibrosis in children with Down's syndrome.Archives of Disease in Childhood, 1975