Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
- 22 July 2008
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 104 (6) , 2016-2026
- https://doi.org/10.1002/jcb.21813
Abstract
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment. J. Cell. Biochem. 104: 2016–2026, 2008.Keywords
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