Introduction to the E2F Family: Protein Structure and Gene Regulation
- 1 January 1996
- book chapter
- Published by Springer Nature
- Vol. 208, 1-30
- https://doi.org/10.1007/978-3-642-79910-5_1
Abstract
The E2F gene family was identified through several different types of investigations, including studies of viral oncogenes, positive and negative growth regulatory proteins, and cellular promoters. As described below and by Cobrinik, Cress and Nevins, and Adams and Kaelin (this volume), the E2F family (which includes at least seven members) has not only been implicated in controlling viral and cellular gene expression, but also is thought to play an important role in growth regulatory processes such as the G1 to S phase transition and programmed cell death. To understand how this gene family can mediate these important events it is first necessary to examine the structure and regulation of the individual family members.Keywords
This publication has 100 references indexed in Scilit:
- Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell lineGenomics, 1995
- Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa proteinCell, 1994
- Differential regulation of E2F transactivation by cyclin/cdk2 complexes.Genes & Development, 1994
- Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinaseCell, 1994
- E2F1, B-MYB and Selective Members of Cyclin/CDK Subunits Are Targets for Protein Kinase C-Mediated Bimodal Growth Regulation in Vascular Endothelial CellsBiochemical and Biophysical Research Communications, 1994
- Identification of a protein fromSaccharomyces cerevisiaewith E2F-like DNA-binding and transactivating propertiesFEBS Letters, 1993
- Retinoblastoma protein switches the E2F site from positive to negative elementNature, 1992
- The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.Genes & Development, 1992
- Interaction of nuclear factors with the regulatory region of the N-myc gene during differentiation of human embryonal carcinoma cellsGene, 1991
- In vitro and in vivo analysis of the control of dihydrofolate reductase gene transcription in serum‐stimulated mouse fibroblastsJournal of Cellular Physiology, 1984