The polyprotein nature of substance P precursors
- 5 February 1989
- Vol. 10 (2-3) , 62-69
- https://doi.org/10.1002/bies.950100207
Abstract
Substance P and related tachykinin peptides probably act as neurotransmitters or modulators of neurotransmission, and regulate biological processes as diverse as salivary secretion and transmission of pain signals. Substance P peptide sequences are expressed in three distinct mRNAs that are generated from one gene by differential RNA splicing. In addition to substance P, as many as three other tachykinin peptides can be generated from the polyprotein precursors by differential posttranslational processing. Three tachykinin receptor subtypes have been extensively characterized which differentially interact with the naturally occurring tachykinin peptides. Therefore, the generation of diversity of tachykinin peptides results from differential precursor RNA splicing and differential posttranslational processing. The specificity of peptide responses is the result of selective receptor subtype expression.Keywords
This publication has 72 references indexed in Scilit:
- Regulation of the Release of Coexisting NeurotransmittersAnnual Review of Pharmacology and Toxicology, 1988
- G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALSAnnual Review of Biochemistry, 1987
- Pharmacological receptors for substance P and neurokininsLife Sciences, 1987
- cDNA sequence of human β-preprotachykinin, the common precursor to substance P and neurokinin AFEBS Letters, 1986
- Sequence analysis of cloned cDNA for rat substance P precursor: Existence of a third substance P precursorBiochemical and Biophysical Research Communications, 1986
- Possible existence of high molecular precursor proteins for substance P biosynthesis in rabbit spinal gangliaNeurochemistry International, 1986
- Neuropeptide K: Isolation, structure and biological activities of a novel brain tachykininBiochemical and Biophysical Research Communications, 1985
- Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicingNature, 1984
- Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cordBiochemical and Biophysical Research Communications, 1984
- The role of hormone receptors and GTP-regulatory proteins in membrane transductionNature, 1980