Urinary Estrogen Excretion in Pregnant Rhesus Monkeys1

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Abstract
The urinary excretion of estrogens was determined in six rhesus monkeys (Macaca mulatta) during and after pregnancy. Of the three “classical” estrogens, only estrone was present in measurable amounts, mostly as glucosiduronate. The urinary concentration of this steroid increased progressively during the last 8–9 weeks of pregnancy and showed a marked rise during the week immediately preceding parturition. This was followed by a sudden decrease in steroid excretion on the day before or on the day of delivery. Estriol was detected in small amounts in all the animals, mostly as sulfate. Estradiol-17β was present but could not be accurately measured because of the interference of an unidentified compound which had chromatographic properties similar to those of estradiol. Three days after parturition, the urinary levels of these estrogens declined to nonpregnancy values.

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