Effects of the 5-HT1A agonist 8-OH-DPAT on food intake in food-deprived rats
- 1 November 1992
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 3 (11) , 1019-1022
- https://doi.org/10.1097/00001756-199211000-00019
Abstract
The effects of 8-OH-DPAT were investigated on food intake in food-deprived rats in both non-operant and operant feeding paradigms. 8-OH-DPAT produced dose-related reductions in food intake in both paradigms. While the higher doses of 8-OH-DPAT used in this study (i.e. 125-500 micrograms kg-1) produced a number of stereotyped behaviours which may have interfered with normal feeding, these behaviours were not apparent with the lower doses (i.e. 15.625-62.5 micrograms kg-1) which also depressed food-intake. The results of this study thus suggest that the inhibitory effect of 8-OH-DPAT on feeding in food-deprived rats is not secondary to the induction of stereotypy.Keywords
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