Induction of Differentiation of Human Null Cells into T Lymphocytes Under the Influence of Serum of Mice Treated with Sodium Diethyldithiocarbamate

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Abstract
Mouse serum collected 24 hr after administration of sodium diethyldithiocarbamate was shown to convert a subset of null cells, not bearing the human T lymphocyte differentiating antigen (HTLA− cells) into HTLA+ cells in man. In addition to inducing surface chracteristics of T lymphocytes, the serum of treated mice increased fumtional activities of human peripheral blood lymphocytes, including the response to Con A and the suppressor activity in vitro.