Evidence of thyroxine formation following iodine administration in Sprague‐Dawley rats

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Abstract
Iodine (I2) has been proposed to be used as a water disinfectant on the manned space station. Previous work has shown that subchronic administration of I2 to Sprague‐Dawley rats in drinking water significantly increases plasma thyroxine/triiodothy‐ronine (T4/T3) levels. This is not observed with iodide (I−) treatment. The present study addresses the possibility that I2 reacts with deiodinated T4 metabolites in the gastrointestinal tract to resynthesize T4. Incubation of diiodothyronine (T2), T3, or reverse T3 with I2 in phosphate‐buffered saline resulted in the formation of T4 as measured by radioimmunoassay. Washes from the initial segments of the small intestine of the rat show that substrates are present that react with I2 to produce T4. Single oral doses of I2 to rats produced significant dose‐related increases in serum T4 and decreases in T3 concentrations after 2 h. Administration of an equivalent dose of I− did not alter significantly plasma T4 concentrations. Higher concentrations of a radioactive substance that bound a T4‐specific antibody are present in plasma of animals treated with 125I2 compared to 125I−. These data support the hypothesis that I2 reacts with metabolites of thyroid hormone in the gastrointestinal tract to resynthesize T4 and elevate its levels in blood.