Percentages of abnormal hemoglobins in adults with a heterozygosity for an α‐chain and/or a β‐chain variant

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Abstract
The author reviews quantitative data from blood samples involving more than 700 simple and compound heterozygotes for one of 21 types of α‐chain and 36 types of β‐chain variants. All samples were analyzed during the past few years by the same analytical procedure. Various factors influencing the percentages of the different abnormal hemoglobins are discussed; these include the variability of the method, the number of active α‐chain genes, the location of the substitution, the type of substitution, the effect of the loss of a critical amino acid residue, and the introduction of a new residue on the physicochemical and/or functional properties of the protein. The use of a single accurate method is promoted; it may well be that high‐pressure liquid chromatographic procedures will be the recommended methods for future analyses.

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