Upon the Nature of Hodgkin’s Disease and the Reed-Sternberg Cell

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Abstract
The pathologic diagnosis of Hodgkin’s disease depends upon the observation of characteristic Reed-Sternberg cells in an appropriate histologic setting. Historically, in 1863, Virchow [57] seems to have been the first to refer to these “large peculiar cells,” which he termed lymphadenoma cells. In 1872, Langhans [18] provided a more detailed description: “grössere Zellen mit 2–4 und mehr Kernen und etwas dunkelkörniger Zellsubstanz, auch wirklich Riesenzellen von länglicher Form.” Six years later, Greenfield [13] also observed similar giant cell forms: “large numbers of multi-nucleated cells (containing from four to eight to twelve nuclei) adherent to the trabeculae”.