Enantioselectivity in a free-radical oxidation: measurement of small enantiomeric excesses
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- Vol. 23 (3) , 393-396
- https://doi.org/10.1039/p29920000393
Abstract
Partial conversion of 2-methyl-1-phenylpropan-1-ol into isobutyrophenone by the acyl aminoxyl radicals formed on oxidation of enantiomerically pure N-fenchelylbenzohydroxamic acid or its para-nitro derivative occurs with small but measurable enantioselectivity. This has been demonstrated using HPLC with diode-laser-based polarimetric detection to examine unchanged alcohol in the reaction mixtures.Keywords
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