Fourteen young females with acute pains in the right hypochondrium were admitted to the Surgical Department. The history and clinical findings were typical of acute perihepatitis (Fitz-Hugh-Curtis syndrome), and the diagnosis was confirmed by laparoscopy. The gynecological symptoms and signs were negligible, and Neisseria gonorrhoeae were cultured from the endocervix in two of the patients. Pathogenes in the suprahepatic space were not demonstrated. Eight patients used intrauterine contraceptive device (IUD) of the Copper-T-type. Acute perihepatitis is an important differential diagnosis in young females presenting with acute pains in the right hypochondrium.