Design and Evaluation of a New Disintegration Test Apparatus for Vaginal Tablets

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Abstract
A new methodology of a disintegration test for vaginal tablets was investigated. Samples from ten commercial vaginal tablets, five of which were effervescent and others non-effervescent types, were employed. A tablet was placed on the 9-mesh metallic net which was held horizontally at a designated position in distilled water at 37 .+-. 0.5.degree. C, and the guided plate was placed on the tablet. The guided plate moved downward smoothly in a cylinder as the tablet disintegrated. The movement was recorded by using the kymograph. The completion of the disintegration was defined at the time when the stable recording had started. The influence of the weight of the guided plate used on the disintegration time was investigated, and its optimum weight was found to be 4.0 g. The desirable position of the metallic net was at a depth of 1.0 mm by considering closer in vivo situation. With this method, the pharmaceutical properties of vaginal tablets were also observed. In comparison with other methods of disintegration test for vaginal tablets, satisfactory results for the proposed method were obtained. Thus, it can be concluded that this method provides a useful tool for the quality control test of vaginal tablets.

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