Identification of Doxapram Metabolites using High Pressure Ion Exchange Chromatography and Mass Spectroscopy
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 3 (2) , 73-83
- https://doi.org/10.3109/00498257309151502
Abstract
1. High pressure ion exchange chromatography has been used for separation of metabolites of doxapram from whole dog urine. Thin layer chromatography was used for additional separation and clean-up. 2. The structures of the metabolites thus isolated were determined by mass spectroscopy. 3. Seven metabolites were separated and identified.Keywords
This publication has 5 references indexed in Scilit:
- Fluorometric Determination of Zinc in Biologic FluidsClinical Chemistry, 1968
- A Series of Central Nervous System Stimulants Based on the 4-Substituted 3,3-Diphenyl-2-pyrrolidinone Skeleton. IIJournal of Medicinal Chemistry, 1967
- Excretion, Distribution, and Metabolism of Doxapram HydrochlorideJournal of Medicinal Chemistry, 1965
- 4-(β-Substituted ethyl)-3,3-diphenyl-2-pyrrolidinones. A New Series of CNS Stimulants1Journal of Medicinal Chemistry, 1964
- Ion Exchange Chromatography of Amino Acids. A Single Column, High Resolving, Fully Automatic Procedure.Analytical Chemistry, 1963