Case report on mixed infection of canine parvovirus and canine coronavirus - Electron microscopy and recovery of canine coronavirus.

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Abstract
Coronavirus-like virions and associated degenerative changes were seen in the enterocytes of jejunal villi of a mongrel dog which had been diagnosed as having canine parvoviral disease based on virological and pathological examinations. A cytopathic agent was isolated in dog kidney cell cultures from the intestinal contents of this case. The isolate, Toda strain, had morphological and physicochemical properties in common with viruses of the coronavirus group. Toda strain was neutralized by ascites obtained from a cat with feline infectious peritonitis. Thus, the case was diagnosed precisely as a mixed infection of canine parvovirus and canine coronavirus.