Short-step synthesis of the ergot alkaloids, (.+-.)-norchanoclavine-I, (.+-.)-chanoclavine-I, (.+-.)-isochanoclavine-I, and (.+-.)-agroclavine.
Open Access
- 1 January 1986
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (2) , 948-950
- https://doi.org/10.1248/cpb.34.948
Abstract
The simple total synthesis of the ergot alkaloids, (±)-norchanoclavine-I, (±)-chanoclavine-I, (±)-isochanoclavine-I, and (±)-agroclavine was achieved by a practical and common synthesis method. A new regio-selective oxidation of the Z-methyl group of the isoprenyl system with selenium dioxide is describedKeywords
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