THE EFFECTS OF RENIN, PITRESSIN, AND PITRESSIN AND ATROPINE ON RENAL BLOOD FLOW AND CLEARANCE

Publisher Website
Google Scholar
Abstract
A modification is described of the Rhoads'' method of making the renal vein accessible by explanting the kidney in dogs. Data obtained during control observations on conscious uninephrectomized [female] dogs showed a direct relation of phenol red and inulin renal plasma clearances to calculated renal plasma flows. Phenol red and inulin renal plasma extraction % were inversely related to calculated renal plasma flows. The slow infusion of renin resulted in decreased renal plasma flow and usually a marked increase in inulin extraction, which was probably due to preponderant constriction of the glomerular efferent arterioles. The slow infusion of pitressin increased or decreased renal plasma flow or left it unchanged although skin temp, was always decreased. Increased inulin extraction was observed during the periods of decreased renal plasma flow obtained during pitressin infusion. The inj. of atropine during the infusion of pitressin resulted in a marked increase of blood pressure and a moderate increase of inulin extraction which was attributed to transmission to the glomerular capillaries of a fraction of the increased systemic arterial pressure.