Mianserin and doxepin in the treatment of outpatient depression with anxiety.

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Abstract
1 A double‐blind group comparative trial was performed comparing mianserin (Bolvidon‐Organon) and doxepin (Sinequan‐Pfizer) in the treatment of depression with anxiety. 2 Sixty outpatients from two centres were divided into ‘high’ and ‘low’ severity groups, based on initial HRS scores, and treated for four weeks. 3 Standard rating scales for depression and anxiety demonstrated a substantial improvement with both drugs. However, no consistent difference in efficacy was found although the ‘low severity’ group appeared to respond better to mianserin. 4 There was a greater incidence of drug‐ related side‐effects with doxepin treatment.