Long hydrocarbon chains serve as unique molecular features recognized by ventral glomeruli of the rat olfactory bulb
- 19 July 2006
- journal article
- research article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 498 (1) , 16-30
- https://doi.org/10.1002/cne.20973
Abstract
In an effort to understand mammalian olfactory processing, we have been describing the responses to systematically different odorants in the glomerular layer of the main olfactory bulb of rats. To understand the processing of pure hydrocarbon structures in this system, we used the [14C]2‐deoxyglucose method to determine glomerular responses to a homologous series of alkanes (from six to 16 carbons) that are straight‐chained hydrocarbons without functional groups. We found two rostral regions of activity evoked by these odorants, one lateral and one medial, that were observed to shift ventrally with increasing alkane carbon chain length. Furthermore, we successfully predicted that the longest alkanes with carbon chain length greater than our previous odorant selections would stimulate extremely ventral glomerular regions where no activation had been observed with the hundreds of odorants that we had previously studied. Overlaps in response profiles were observed in the patterns evoked by alkanes and by other aliphatic odorants of corresponding carbon chain length despite possessing different oxygen‐containing functional groups, which demonstrated that hydrocarbon chains could serve as molecular features in the combinatorial coding of odorant information. We found a close and predictable relationship among the molecular properties of odorants, their induced neural activity, and their perceptual similarities. J. Comp. Neurol. 498:16–30, 2006.Keywords
This publication has 75 references indexed in Scilit:
- Interactions between odorant functional group and hydrocarbon structure influence activity in glomerular response modules in the rat olfactory bulbJournal of Comparative Neurology, 2005
- Local and global chemotopic organization: General features of the glomerular representations of aliphatic odorants differing in carbon numberJournal of Comparative Neurology, 2004
- Topographic Representation of Odorant Molecular Features in the Rat Olfactory BulbJournal of Neurophysiology, 2004
- Olfactory coding in the mammalian olfactory bulbBrain Research Reviews, 2003
- The spatial representation of chemical structures in the antennal lobe of honeybees: steps towards the olfactory codeEuropean Journal of Neuroscience, 1999
- A Numerical Model of Nasal Odorant Transport for the Analysis of Human OlfactionJournal of Theoretical Biology, 1997
- A Mass Transport Model of OlfactionJournal of Theoretical Biology, 1994
- Factors influencing the differential sorption of odorant molecules across the olfactory mucosa.The Journal of general physiology, 1977
- Chromatographic Separation of Odorants by the Nose: Retention Times Measured across in vivo Olfactory MucosaScience, 1973
- Multiple profile-multiple receptor site model for vertebrate olfactionJournal of Theoretical Biology, 1973