Relationship of Normal Human Serum Immunoglobulins to Blocking of Prausnitz-Küstner Sensitization

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Abstract
DEAE-Sephadex fractions of 2 normal human sera were studied for their capacity to block Prausnitz-Kustner sensitization with ragweed reagins. Fractions containing the bulk of [gamma] G globulin only as well as fractions with both [gamma] G and A globulin were active. A fraction derived from each serum and containing a minimum of [gamma] G, approximately half the [gamma] A and all of the [gamma]M globulins had no or minimal blocking activity. A time study indicated that the blocking factor fixed to skin for 5-10 days. The relationship between blocking activity and the immunoglobulins of normal human serum was discussed.