Opiates, Prolactin, and the Dopamine Receptor*
- 1 July 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 47 (1) , 200-203
- https://doi.org/10.1210/jcem-47-1-200
Abstract
The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90–150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, and bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.Keywords
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