Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients

Open Access

1 May 2004

journal article
research article
Published by American Society for Microbiology in Clinical and Vaccine Immunology

Vol. 11 (3) , 625-626
https://doi.org/10.1128/cdli.11.3.625-626.2004

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls ( P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

Keywords

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