Opposite Effects of Extracellular Sodium Removal on the Uptake of Tryptophan into Rat Cortical Slices and Synaptosomes
- 1 July 1984
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 43 (1) , 274-275
- https://doi.org/10.1111/j.1471-4159.1984.tb06708.x
Abstract
The removal of extracellular sodium decreased L-tryptophan (L-TRP) uptake into brain slices but increased uptake into synaptosomes. The uptake of 5-hydroxytryptamine (5-HT) was inhibited in both preparations under these conditions. It is suggested that the different effects on L-TRP uptake may be due to differences in cellular composition between the two preparations rather than to any differences in sample handling.Keywords
This publication has 6 references indexed in Scilit:
- Kinetics of Tryptophan Influx into Brain Slices Depleted of Sodium and Loaded withl‐HistidineJournal of Neurochemistry, 1983
- Enhancement of Tryptophan Uptake by Divalent Cations in the Absence of Sodium IonsJournal of Neurochemistry, 1980
- REGIONAL TRANSPORT OF TRYPTOPHAN IN RAT BRAINJournal of Neurochemistry, 1977
- Role of sodium in neuronal uptake of monoamines and amino acid precursorsNature, 1975
- INHIBITION OF AMINO ACID UPTAKE BY THE ABSENCE OF Na+ IN SLICES OF BRAINJournal of Neurochemistry, 1975
- TRANSPORT OF l‐TRYPTOPHAN INTO SLICES OF RAT CEREBRAL CORTEX1Journal of Neurochemistry, 1972